Protein Synthesis

Encompassing all aspects of the structures of peptides and proteins, this book adopts a uniquely problem-oriented approach to the topic. Starting with a look at the structures and properties of the twenty amino acids that occur in proteins, and moving on to the synthesis of polypeptides and the isolation of proteins, Peptides and Proteins then addresses the methods of analysis of protein characteristics, including the modern methods of sequence analysis by mass spectrometry. Further chapters examine the three-dimensional nature of protein structure, and introduce the student to the use of computer applications (molecular graphics, databases, bioinformatics) in protein chemistry. Original research data is used in many of the problems, and throughout sufficient background biology is included, thus putting the subject into context for chemists. Aimed at first and second-year chemistry students, this title will also be of interest to students of biochemistry.

Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

Protein synthesis - Biological and artificial methods for creation of proteins differ significantly.

Acyl carrier protein - The acyl carrier protein is an important component in both fatty acid biosynthesis and polyketide synthases, with the growing polyketide chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phophopantethiene moiety. The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a highly conserved serine residue on the ACP by acyl carrier protein synthase (ACPS) a phosphopantetheinyl transferase.

Solid phase peptide synthesis - Solid-phase peptide synthesis (SPPS) is the accepted method for creating peptides and proteins in the lab in a synthetic manner. This allows the synthesis of natural peptides which are difficult to express in bacteria, incorporation of unnatural amino acids, peptide/protein backbone modification, and the synthesis of D-proteins, which consist of D-amino acids.

CGMP-dependent protein kinase - cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division ,and nucleic acid synthesis.

proteinsynthesis

Plasma Protein - Plasma Protein C-reactive protein - C-reactive protein (CRP) is a plasma protein, an acute phase protein produced by the liver. It is a member of the pentraxin family of proteins. Integral membrane protein - An Integral Membrane Protein (IMP) is a protein molecule (or assembly of proteins) that in most cases spans the biological membrane with which it is associated (especially the plasma membrane) or which, in any case, is sufficiently embedded in the membrane to remain with it during the ...

Plasma Protein Fraction Human - Plasma Protein Fraction Human Integral membrane protein - An Integral Membrane Protein (IMP) is a protein molecule (or assembly of proteins) that in most cases spans the biological membrane with which it is associated (especially the plasma membrane) or which, in any case, is sufficiently embedded in the membrane to remain with it during the initial steps of biochemical purification (compare peripheral membrane protein). C-reactive protein - C-reactive protein (CRP) is a plasma protein, an acute phase protein produced by the ...

Condensation Synthesis - Condensation Synthesis Pechmann condensation - The Pechmann condensation is a synthesis of coumarins, starting from a phenol and a carboxylic acid or ester containing a β-carbonyl group. The condensation is performed under acidic conditions. Feist-Benary synthesis - The Feist-Benary synthesis is an organic reaction between α-halogen ketones and β-dicarbonyl compounds to substituted furan compounds . This condensation reaction is catalyzed by amines such as ammonia and pyridine. Condensation reaction - A condensation reaction (also known as a dehydration reaction or ...

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